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Thread: Research - Cannabis Attenuates MDMA-induced Neurotoxicity

  1. #1
    Experienced Psychonaut IJesusChrist's Avatar
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    Re: Research - Cannabis Attenuates MDMA-induced Neurotoxicit

    Interesting... I wonder somewhat if the last sentence of the paragraph is a bit biased though... but still interesting.
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  2. #2
    Skilled Psychonaut
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    Re: Research - Cannabis Attenuates MDMA-induced Neurotoxicit

    Ya, i get what you mean, but it does say that it "can provide some protection", not that it necessarily does . It's also the first study of this kind that I know of, so it remains to be seen if further studies researching the same thing get the same results.. It's certainly not bad news though for a preliminary study

  3. #3
    Skilled Psychonaut
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    Re: Research - Cannabis Attenuates MDMA-induced Neurotoxicit

    Huh?.. why was the initial post removed? Here it is again (not able to attach the actual article itself now though.. was it removed because of copyright issues or something alike??.. Just let me know if you want it - EDIT: Able to attach it again, bottom of post)


    ABSTRACT: Most recreational users of 3, 4-methylenedioxymethamphetamine (MDMA or "ecstasy") also take cannabis, in part because cannabis can reduce the dysphoric symptoms of the ecstasy come-down such as agitation and insomnia. Although previous animal studies have examined the acute effects of co-administering MDMA and ?(9)-tetrahydrocannabinol (THC), which is the major psychoactive ingredient in cannabis, research on chronic exposure to this drug combination is lacking. Therefore, the present study was conducted to investigate the effects of chronic adolescent administration of both THC and MDMA on behavior and on regional serotonin transporter (SERT) binding and serotonin (5-HT) concentrations as indices of serotonergic system integrity. Male Sprague-Dawley rats were divided into four drug administration groups: (1) MDMA alone, (2) THC alone, (3) MDMA plus THC, and (4) vehicle controls. MDMA (2×10mg/kg×4h) was administered every fifth day from postnatal day (PD) 35 to 60 to simulate intermittent recreational ecstasy use, whereas THC (5mg/kg) was given once daily over the same time period to simulate heavy cannabis use. THC unexpectedly produced a modest hyperthermic effect when administered alone, but in animals co-treated with both THC and MDMA, there was an attenuation of MDMA-induced hyperthermia on dosing days. Subsequent testing conducted after a drug washout period revealed that THC reduced MDMA-related behavioral changes in the emergence and social interaction tests of anxiety-like behavior and also blunted the MDMA-induced decrease in exploratory behavior in the hole-board test. THC additionally attenuated MDMA -induced decreases in 5-HT levels and in SERT binding in the frontal cortex, parietal cortex, and striatum, but not in the hippocampus. These results suggest that chronic co-administration of THC during adolescence can provide some protection against various adverse physiological, behavioral, and neurochemical effects produced by MDMA.

    Source: PubMed - July 13th 2011 - http://www.ncbi.nlm.nih.gov/pubmed/21763331

    [attachment=0:5qo3x0iw]Shen, Ali & Meyer (2011).pdf[/attachment:5qo3x0iw]
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