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Thread: 4-Fluorotropacocaine

  1. #1
    Improving Psychonaut Donny226's Avatar
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    4-Fluorotropacocaine

    Voila un ami psychonaut m'a parlé de cette substance mais je ne trouve des infos qu'en anglais sur le net, donc si une ame charitable pouvais m'éclairer :

    - Un stimulant anestesique ??? Entant qu' adepte du "Speedcial K" (amphet + kéta)j'aimerais avoir quelques précisions sur les éffets.

    - Elle est indisponible sur plusieurs shop, trop de demande ?? Encore légal ??

    Si quelqun a déjà testé et pourrais me faire un petit trip report

    Merci d'avance !
    "I have come a long way, between this Earth and Zion"

  2. #2

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    Re: 4-Fluorotropacocaine

    c' est de la MERDE parole de cocaïnomanbe qui se revendique comme tel !

    3-Pseudotropyl-4-fluorobenzoate
    AKA ,
    ---4-fluorotropacocaine
    ---pFBT
    --- 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 4-fluorobenzoic acid ester

    IUPAC: (1R,5S)-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-4-fluorobenzoate

    CAS ;172883-97-5

    30% the stimulant potency of cocaine but around the same potency as a local anaesthetic

    En gros pour un effet stim comparable , tu crèves d'une vasoconstriction cardiaque avant car ça a aussi des effets vasoconstricteurs peripheripheriques et centraux , pas seulement locaux

    C'est DANGEUREUX.

    et ca ne touche pas a tes 5HT1 comme la coke le fait , seulement a tes dopaminergiques .

    allé un peu de culture (non pas hors sujet justement , extention = compréhension )


    Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.
    Agoston GE, Wu JH, Izenwasser S, George C, Katz J, Kline RH, Newman AH.

    Psychobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.

    A series of N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues has been prepared that function as dopamine uptake inhibitors.

    The N-methylated analogue of this series had a significantly higher affinity for the dopamine transporter than the parent compound, N-methyl-3 alpha- (diphenylmethoxy)tropane (benztropine, Cogentin).

    Yet like the parent compound, it retained high affinity for muscarinic receptors. A series of N-substituted compounds were prepared from nor-3 alpha-[bis(4'-fluorophenyl)methoxy]tropane via acylation followed by hydride reduction of the amide or by direct alkylation. All compounds containing a basic tropane nitrogen displaced [3H]WIN 35,428 at the dopamine transporter (Ki range = 8.5-634 nM) and blocked dopamine uptake (IC50 range = 10-371 nM) in rat caudate putamen, whereas ligands with a nonbasic nitrogen were virtually inactive.

    None of the compounds demonstrated high binding affinity at norepinephrine or serotonin transporters.

    Importantly, a separation of binding affinities for the dopamine transporter versus muscarinic m1 receptors was achieved by substitution of the N-methyl group with other N-alkyl or arylalkyl substituents (eg. n-butyl, allyl, benzyl, 3-phenylpropyl, etc.).

    Additionally, the most potent and selective analogue in this series at the dopamine transporter, N-(4"-phenyl-n-butyl)-3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogue failed to substitute for cocaine in rats trained to discriminate cocaine from saline.

    Potentially, new leads toward the development of a pharmacotherapeutic for cocaine abuse and other disorders affecting the dopamine transporter may be discovered.

    PMID: 9435902 [PubMed - indexed for MEDLINE]

    pour les curieux qui veulent apprendre par eux même , petite selection sympa :

    http://www.ncbi.nlm.nih.gov/pubmed/2755 ... rom=pubmed
    http://dx.doi.org/10.1007%2Fs002130000568
    http://www.springerlink.com/content/jl27305140p02v87/
    http://dx.doi.org/10.1007%2FBF01936761
    http://www.ncbi.nlm.nih.gov/pubmed/1913 ... tlesearch4
    http://www.ncbi.nlm.nih.gov/pubmed/8848 ... rom=pubmed
    http://chem.sis.nlm.nih.gov/chemidplus/ ... 0000053214
    http://www.ncbi.nlm.nih.gov/pubmed/1943051
    http://www.ncbi.nlm.nih.gov/pubmed/2755088
    http://www.ncbi.nlm.nih.gov/pubmed/7116761


    a lire

    --Rodriguez de Fonseca, F.; Carrera, M.R.A.; Navarro, M.; Koob, G.F.; and Weiss, F. Activation of corticotropin releasing factor in the limbic system during cannabinoid withdrawal. Science 276:2050 -2054, 1997.
    --Koob, G.F., and Bloom, F.E. Cellular and molecular mechanisms of drug dependence. Science 242:715- 723, 1988.
    --Koob, G.F.; Markou, A.; Weiss, F.; and Schultei s, G. Opponent process and drug dependence: Neurobiological mechanisms. Semin Neurosci 5:351-35 8, 1993.
    --Markou, A., and Koob, G.F. Postcocaine anhedonia: An animal model of cocaine withdrawal. Neuropsychopharmacolog y 4:17-26, 1991.
    --Markou, A., and Koob, G.F. Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal. Neuropsychopharmacolog y 7:213-22 4, 1992.
    --Pich, E.M.; Lorang, M.; Yeganeh, M.; Rodriguez de Fonseca, F.; Raber, J.; Koob, G.F.; and Weiss, F. Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci 15:5439- 5447, 1995.
    --Parsons, L.H.; Kerr, T.M.; Weiss, F.; and Koob, G.F. Serotonin -1B receptor stimulation enhances cocaine reinforcement: Behavioral and neurochemical studies in rats. J Neurosci, submitted.
    --Parsons, L.H.; Koob, G.F.; and Weiss, F. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. J Pharmac ol Exp Ther 274:1182 -1191, 1995.
    --Richter, R.M.; Pich, E.M.; Koob, G.F.; and Weiss, F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis. Neurosci Lett 187:169- 172, 1995.
    --Richter, R.M., and Weiss, F. In vivo CRF release in rat amygdala is increased during withdrawal after cocaine self-administration with unlimited access. J Neurosci, submitted.
    --Weiss, F.; Hurd, Y.L.; Ungerstedt, U.; Markou, A.; Plotsky, P.M.; and Koob, G.F. Neurochemical correlates of cocaine and ethanol self-administration . In: The Neurobiology of Drug and Alcohol Addiction. Kalivas, P.W., and Samson, H.H., eds. Ann N Y Acad Sci 654:220- 241, 1992a.
    --Weiss, F.; Imperato, A.; Casu, M.A.; Mascia, M.S.; and Gessa, G.L. Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats. Eur J Pharmacol 337:219- 222, 1997.
    --Weiss, F.; Markou, A.; Lorang, M.T.; and Koob, G.F. Basal extracellular dopamine levels in the nucleus acumbens are decreased during cocaine withdrawal after unlimited- access self-administration . Brain Res 593:314- 318, 1992b.
    --Weiss, F.; Parsons, L.H.; and Markou, A. Neurochemistry of cocaine withdrawal. In: The Neurobiology of Cocaine: Cellular and Molecular Mechanisms. Hammer, Jr., R.L., ed. Boca Raton, FL: CRC Press, 1995. pp. 163-180.
    --Wise, R.A. Neurobiology of addiction. Curr Opin Neurobiol6:243-251, 1996.

  3. #3

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    Re: 4-Fluorotropacocaine

    si l' ami psychonaut te propose de t'en vendre c' est pas un ami .
    Si il est connu comme P.C initiales , c' est un abrutit qui plus est .

    C' etait le post RDR

  4. #4

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    Re: 4-Fluorotropacocaine

    desolé Oogie pas envi de creer un topic juste pour ça mais est-ce que t'aurais plus d'infos sur la 4-fma et je precise bien 4-fMa merci :wink:

  5. #5

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    Re: 4-Fluorotropacocaine

    Quote Originally Posted by Dyson
    desolé Oogie pas envi de creer un topic juste pour ça mais est-ce que t'aurais plus d'infos sur la 4-fma et je precise bien 4-fMa merci :wink:
    4MA , j'ai pas mal tartiné 4-FMA pas encore mais g ça qui traine dans l'index , need check mes liens.

    4MA: 1-(4-methylphenyl)propan-2-amine
    CAS : 22683-78-9
    C10.H15.N
    Molm = 149.23 g/mol

    http://www.ncbi.nlm.nih.gov/entrez/euti ... d=15677348
    http://www.ncbi.nlm.nih.gov/entrez/euti ... d=14890975
    http://www.ncbi.nlm.nih.gov/pubmed/15677348
    http://www.ncbi.nlm.nih.gov/pubmed/15677348

    mais sinonon 4-fluoroMethAmphet' , a part que c' est une 4 fluor substituée (aka SuxXuNbOuK) et que ...
    enfin tu veux savoir quoi ?
    Les effets ?
    Jamais essayé mais facile a deviner :
    ---speed/2-FA/4-FA (4fa suxxamort)
    ---cathinone /2FMC / 3FMC/4FMC (flephedrone 4FMC suxxdébouk)
    ---meth/a-meth (phentermine)/2-MA ....et pas essayé encore 4-FMA , mais suivant le raisonement , grosses chaleurs en perspectives , et bon shoot bien violent dans le systeme sympathique et SN-Central & Periphérique .

    Go check pubmed :
    iupac : racemate de 1-(4-fluorophenyl)-N-methylpropan-2-amine
    CAS = 351-03-1

    j'en sais pas plus

  6. #6

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    Re: 4-Fluorotropacocaine

    a titre de comparaison en version cetone j'ai ça . (mais presque rien noté sur 4FMA et la flemme la dessuite)

    3-FMC
    IUPAC ; (+/-)-1-(3-fluorophenyl)-2-methylaminopropan-1-one
    CAS ; 1049677-77-1
    F C10 H12 F NO
    Molmass 181.206
    http://www.ncbi.nlm.nih.gov/pubmed/19195800
    http://www.bluelight.ru/vb/showthread.php?t=458536
    http://www.justice.gov/dea/pubs/scheduling.html

    4-FMC (analogue cetone de 4-FMA donc idem , en pire)
    IUPAC; (+/-) -1-(4-fluorophenyl)-2-methylaminopropan-1-one
    F C10 H12 F N O
    Molmass 181.206
    http://www.ncbi.nlm.nih.gov/pubmed/19195800

  7. #7
    Besorah's Avatar
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    Re: 4-Fluorotropacocaine

    et FMA FMP?
    Là j'avoue je saisis pas la nuance. Amph et Methamph?
    Pourtant je lis plus Methamph et Methamph.
    C'est FA tout court non?
    Je sais plus.

    edit: Methamph et Methylphenethyl plutôt pardon.
    Connais tu l'histoire d'A'neglakya et d'A'neglakyatsi'tsa?
    Sais tu comment les Êtres Divins les punirent?

  8. #8

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    Re: 4-Fluorotropacocaine

    Quote Originally Posted by Besorah
    et FMA FMP?
    Là j'avoue je saisis pas la nuance. Amph et Methamph?
    Pourtant je lis plus Methamph et Methamph.
    C'est FA tout court non?
    Je sais plus.
    4-FMP (suxx cette abrev) c' est para-fluoroamphetamine aka 4-FA

    4-FMA plus logique par contre designe 4-Fluoro.Meth.Amphetamine

    j'avoue ...ça pue 4-FMP

    4-FMP :
    4FA
    1-(4-Fluorophenyl)propane-2-amine
    aka p-Fluoroamphetamine
    F C9 H12 F N
    MW 153.20
    CAS 459-02-
    Boiling point 215 ºC
    Flash point 94 ºC

  9. #9
    Besorah's Avatar
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    Re: 4-Fluorotropacocaine

    Ok, PFA quoi!! lol

    Merci de l'éclaircissement

    edit: re m**de.
    Connais tu l'histoire d'A'neglakya et d'A'neglakyatsi'tsa?
    Sais tu comment les Êtres Divins les punirent?

  10. #10

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    Re: 4-Fluorotropacocaine

    ouais l'embrouille totale si tes pas dans le bulbe ou la marmite

    FLOOD

    3-methyl-2-phenylmorpholine c'est ma copine ,
    préludine quand elle m'allume je m'illumine !


    :arrow:

  11. #11
    Skilled Psychonaut Chips's Avatar
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    Re: 4-Fluorotropacocaine

    C'était commun il y a 1 voir 2 ans de ça. ça restait moyen.

    La dimethocaine a plus de potentiel récréatif, malheureusement elle a aussi plus de potentiel au niveau léthal (coté anesthesiant local trop prononcé).

    Bref, faudrait trouver d'autres RC du genre...
    How can I change the world if I can't even change myself?

  12. #12
    Skilled Psychonaut
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    Re: 4-Fluorotropacocaine

    alors, au niveau RC, il en sont ou maintenant concernat un bon analogue de Blanche Neige ???

  13. #13
    CheesePizza
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  15. #15
    Polytoxiconaute schtroumpfette's Avatar
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    Re: 4-Fluorotropacocaine

    WHAT ?!
    Lucid in the s[K]y [-Hole] of the White Rabbit

  16. #16
    Not For Human crew 5tr4t0's Avatar
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    Re: 4-Fluorotropacocaine

    Cherche pas, un bot alien s'est incrusté. Banned.
    =>Not For Human<=

    On ne peut être fier que de ce qu'on a choisi


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