In studies of its pharmacology in vitro methylone was threefold less potent than MDMA at inhibiting platelet serotonin transporter (SERT) and as potent as MDMA in inhibiting transporters for dopamine (DAT) and norepinephrine (NET), but only weakly inhibited the vesicular monoamine transporter...In addition, the cytotoxicity of MDMA is considered a consequence of monoaminergic deficits through the drug’s effects on the plasmalemmmal and vesicular monoamine transporters. Again, methylone may resemble MDMA in cytotoxic profiles. However, Nakagawa et al
. reported that methylone did not exhibit cytotoxic effects on isolated rat hepatocytes in contrast to MDMA and its analogues. The possibility can not be excluded that methylone is cytotoxic in some circumstances, since Nagai et al
. observed that like MDMA, it reduced mitochondrial membrane potential.